Department of Biochemistry and Molecular Biology · The University of Texas Medical Branch, Galveston, TX
Physics of the living genome
We combine concepts of statistical physics, numerical techniques, dynamics simulations, and AI models with experimental data to learn the physics connecting DNA structure and function.
DNA structure
DNA supercoiling
molecular dynamics
statistical physics
data-driven modeling
Research
Energy landscape modeling
Simulating coarse-grained chromosome folding and 3D genome organization
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Active mechanisms
How protein-DNA interactions shape genome folding and gene expression dynamics
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Physics-based AI
AI models grounded in physical principles to predict and interpret genomic data
Read more →Recent publications
Exploring the Energy Landscape of Bacterial Chromosome Segregation
PNAS · 2026
DNA Supercoiling-Mediated G4/R-loop Formation Tunes Transcription by Controlling the Access of RNA Polymerase
Nature Commun · 2025
Nucleosomes Play a Dual Role in Regulating Transcription Dynamics
PNAS · 2024
Temporally Correlated Active Forces Drive Segregation and Enhanced Dynamics in Chromosome Polymers
PRX Life · 2024
News
2026 Jun
Lab opens at UTMB